Publications – Keeler Lab

SELECTED PUBLICATIONS

A single-cell mass cytometry-based atlas of the developing mouse brain

Van Deusen, A. L.; Kumar, S.; Calhan, O. Y.; Goggin, S. M.; Shi, J.; Williams, C. M.; et al. (2024). A single-cell mass cytometry-based atlas of the developing mouse brain. Nature Neuroscience, 28(1), 174–188. DOI: 10.1038/s41593-024-01786-1. Open paper

Sexual dimorphism in the dorsal root ganglia of neonatal mice identified by protein expression profiling with single-cell mass cytometry

Vradenburgh, S. A.; Deusen, A. L. V.; Beachum, A. N.; Moats, J. M.; Hirt, A. K.; Deppmann, C. D.; et al. (2023). Sexual dimorphism in the dorsal root ganglia of neonatal mice identified by protein expression profiling with single-cell mass cytometry. Molecular and Cellular Neuroscience, 126, 103866. DOI: 10.1016/j.mcn.2023.103866. Open paper

A developmental atlas of somatosensory diversification and maturation in the dorsal root ganglia by single-cell mass cytometry

Keeler, A. B.; Deusen, A. L. V.; Gadani, I. C.; Williams, C. M.; Goggin, S. M.; Hirt, A. K.; et al. (2022). A developmental atlas of somatosensory diversification and maturation in the dorsal root ganglia by single-cell mass cytometry. Nature Neuroscience, 25(11), 1543–1558. DOI: 10.1038/s41593-022-01181-8. Open paper

KEELER LAB AT THE UNIVERSITY OF DELAWARE

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POSTDOCTORAL WORK AT THE UNIVERSITY OF VIRGINIA

A brain reward circuit inhibited by next-generation weight-loss drugs in mice

Godschall, E. N.; Gungul, T. B.; Sajonia, I. R.; Buyukaksakal, A. K.; Li, O.; Ogilvie, S.; et al. (2026). A brain reward circuit inhibited by next-generation weight-loss drugs in mice. Nature. DOI: 10.1038/s41586-026-10444-4. Open paper

A single-cell mass cytometry-based atlas of the developing mouse brain

Stress-induced mucin 13 reductions drive intestinal microbiome shifts and despair behaviors

Rivet-Noor, C. R.; Merchak, A. R.; Render, C.; Gay, N. M.; Beiter, R. M.; Brown, R. M.; et al. (2024). Stress-induced mucin 13 reductions drive intestinal microbiome shifts and despair behaviors. Brain, Behavior, and Immunity, 119, 665–680. DOI: 10.1016/j.bbi.2024.03.028. Open paper

Sexual dimorphism in the dorsal root ganglia of neonatal mice identified by protein expression profiling with single-cell mass cytometry

Sympathetic neurons secrete retrogradely transported TrkA on extracellular vesicles

Mason, A. J.; Keeler, A. B.; Kabir, F.; Winckler, B.; Deppmann, C. (2023). Sympathetic neurons secrete retrogradely transported TrkA on extracellular vesicles. Scientific Reports, 13(1). DOI: 10.1038/s41598-023-30728-3. Open paper

A developmental atlas of somatosensory diversification and maturation in the dorsal root ganglia by single-cell mass cytometry

Molecular dissection of TNFR-TNFα bidirectional signaling reveals both cooperative and antagonistic interactions with p75 neurotrophic factor receptor in axon patterning

Kuhn, K.; Edamura, K.; Bhatia, N.; Cheng, I.; Clark, S.; Haynes, C.; et al. (2020). Molecular dissection of TNFR-TNF$α$ bidirectional signaling reveals both cooperative and antagonistic interactions with p75 neurotrophic factor receptor in axon patterning. Molecular and Cellular Neuroscience, 103, 103467. DOI: 10.1016/j.mcn.2020.103467. Open paper

Transcytosis of TrkA leads to diversification of dendritic signaling endosomes

Barford, K.; Keeler, A.; McMahon, L.; McDaniel, K.; Yap, C. C.; Deppmann, C. D.; et al. (2018). Transcytosis of TrkA leads to diversification of dendritic signaling endosomes. Scientific Reports, 8(1). DOI: 10.1038/s41598-018-23036-8. Open paper

TrkA Bumps into Its Future Self

Barford, K.; Keeler, A.; Deppmann, C.; Winckler, B. (2017). TrkA Bumps into Its Future Self. Developmental Cell, 42(6), 557–558. DOI: 10.1016/j.devcel.2017.09.002. Open paper

Delineating neurotrophin-3 dependent signaling pathways underlying sympathetic axon growth along intermediate targets

Keeler, A. B.; Suo, D.; Park, J.; Deppmann, C. D. (2017). Delineating neurotrophin-3 dependent signaling pathways underlying sympathetic axon growth along intermediate targets. Molecular and Cellular Neuroscience, 82, 66–75. DOI: 10.1016/j.mcn.2017.04.011. Open paper

Mapping the Role of MAP7 in Axon Collateral Branching

Cheng, I.; Keeler, A. B. (2017). Mapping the Role of MAP7 in Axon Collateral Branching. The Journal of Neuroscience, 37(26), 6180–6182. DOI: 10.1523/jneurosci.0944-17.2017. Open paper

The evolutionary origins of antagonistic neurotrophin signaling

Keeler, A. B.; Deppmann, C. D. (2017). The evolutionary origins of antagonistic neurotrophin signaling. Journal of Cell Biology, 216(5), 1223–1225. DOI: 10.1083/jcb.201702115. Open paper

Homophilic Protocadherin Cell-Cell Interactions Promote Dendrite Complexity

Molumby, M. J.; Keeler, A. B.; Weiner, J. A. (2016). Homophilic Protocadherin Cell-Cell Interactions Promote Dendrite Complexity. Cell Reports, 15(5), 1037–1050. DOI: 10.1016/j.celrep.2016.03.093. Open paper

Protein Kinase C Phosphorylation of a γ-Protocadherin C-terminal Lipid Binding Domain Regulates Focal Adhesion Kinase Inhibition and Dendrite Arborization

Keeler, A. B.; Schreiner, D.; Weiner, J. A. (2015). Protein Kinase C Phosphorylation of a γ-Protocadherin C-terminal Lipid Binding Domain Regulates Focal Adhesion Kinase Inhibition and Dendrite Arborization. Journal of Biological Chemistry, 290(34), 20674–20686. DOI: 10.1074/jbc.m115.642306. Open paper

Protocadherins branch out: Multiple roles in dendrite development

Keeler, A. B.; Molumby, M. J.; Weiner, J. A. (2015). Protocadherins branch out: Multiple roles in dendrite development. Cell Adhesion & Migration, 9(3), 214–226. DOI: 10.1080/19336918.2014.1000069. Open paper